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DNA immunoadsorption for childhood-onset systemic lupus erythematosus

time :  2017-01-16

Xue-Mei Tang, Zong-Yi Zou, Xiao-Dong Zhao, Xue-Lan Chen, Yu Zhang, Qiu Li

Key Laboratory of Pediatrics in Chongqing, Department of Immunology, Children’s Hospital of Chongqing Medical University, Chongqing, China


ABSTRACT

We present a retrospective review of DNA immu-noadsorption (DNA-IA) therapy on clinical symptoms as well as indicators in pediatric cases with systemic lupus erythematosus (SLE), and follow up the short- term curative effects. 16 SLE cases were treated by DNA-IA for 3 times every other day. We observed the changes on clinical manifestations and immunological indicators, in order to compare the alteration of these indicators including clinical manifestations, Systemic Lupus Erythematosus Disease Active Index (SLEDAI) scores, 24 h-urinary protein excretion, autoantibodies, serum IgG and complement C3. 13 cases were fol-lowed up regularly, within 3 months after DNA-IA therapy, 12 cases of clinical manifestations improved (92.3%). SLEDAI scores in 10 cases decreased from (16.20 ± 12.54) to less than 5 (76.9%), 8 cases of ANA, anti-DNA antibodies were negative (61.5%), 13 cases with IgG level in serum recovered to normal (10.39 ± 4.38) g/L, C3 level rose to normal (1.06 ± 0.23) g/L. 3 to 6 months after IA, clinical manifestations and labo-ratory examinations in all cases got maximum im-proved. 9 months after IA, SLEDAI score in 2 cases (15.4%) rose to more than 5, anti-DNA antibody in 2 cases (15.4%) became positive, and 1case (7.7%) with serum C3 decreased again. 2 cases died from multiple organs dysfunction within 3 to 6 months after IA. No serious complications were found during DNA-IA. We recommend that DNA immunoadsorption is a safe and effective therapy for active childhood-onset SLE, which could improve clinical symptoms, elimi nate ANA and anti-DNA antibodies. Combining with corticosteroids and immunosuppressive drugs, DNA- IA could significantly reduce the activity of disease and protect vital organs function in the short term.

Keywords: DNA Immunoadsorption (DNA-IA); Systemic Lupus Erythematosus (SLE); Childhood-Onset; Autoantibody


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